Smallpox virus, which killed millions of humans through the ages, ranks among the world\u2019s most feared bioterrorism agents. Human monkeypox continues to occur sporadically in remote African villages.<\/p>\n
In a new report, virologists from the Long School of Medicine and their collaborators at Oklahoma State University demonstrate how poxviruses such as smallpox defeat the body\u2019s host immune defenses. The implications extend beyond viral infections to cancer therapy, said senior author Yan Xiang, Ph.D., associate professor in the Department of Microbiology and Immunology.<\/p>\n
Dr. Xiang and colleagues revealed how a molecule on the poxviruses defeats a host restriction factor called SAMD9 in humans and animals. SAMD9 protects against viruses, and suppresses tumors. Mutations in the human SAMD9 gene are responsible for a life-threatening cancer called normophosphatemic familial tumoral calcinosis.<\/p>\n
\u201cThere is an \u2018arms race\u2019 occurring between pathogens [disease-causing agents] and their hosts,\u201d Dr. Xiang said. \u201cTo survive in their hosts, many pathogens utilize specific inhibitors of the host restriction factors. SAMD9 is an evolutionally conserved immune barrier, but it has been successfully overcome by diverse poxviruses.\u201d<\/p>\n
First author of the study is Xiangzhi Meng, M.D., Ph.D., an assistant professor in microbiology and immunology.<\/p>\n
The discovery was published in Proceedings of the National Academy of Sciences<\/i>.<\/p>\n","protected":false},"excerpt":{"rendered":"
Virologists discover how poxviruses defeat the body\u2019s immune defenses, and the implications may extend to new cancer therapies.<\/p>\n","protected":false},"author":23,"featured_media":10234,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[63,206],"tags":[],"ppma_author":[],"class_list":["post-9886","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-university-in-motion","category-springsummer-2016"],"yoast_head":"\n