{"id":4875,"date":"2016-01-07T14:20:50","date_gmt":"2016-01-07T14:20:50","guid":{"rendered":"<img class=\"alignright size-full wp-image-5450\" src=\"http:\/\/magazines.uthscsa.edu\/mission-new\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg\" alt=\"stomache-ache-600px\" width=\"600\" height=\"400\" \/>Most patients with longstanding Type 1 diabetes"},"modified":"2016-05-27T20:12:26","modified_gmt":"2016-05-27T20:12:26","slug":"chronic-complication-in-diabetics-explained","status":"publish","type":"post","link":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/","title":{"rendered":"Chronic complication in diabetics explained"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignright size-full wp-image-5450\" src=\"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg\" alt=\"stomache-ache-600px\" width=\"600\" height=\"400\" srcset=\"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg 600w, https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px-150x100.jpg 150w, https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>Most patients with longstanding Type 1 diabetes have chronic gastrointestinal symptoms that significantly reduce their quality of life. And now researchers have a better understanding of why this happens.<\/p>\n<p>These complications, called diabetic enteropathy, include the delayed emptying of food, irritable bowel syndrome, abdominal distension and fecal incontinence. The cause was previously unknown.<\/p>\n<p>Intestinal tissues from diabetic patients and healthy people were compared in a study co-authored by <a href=\"https:\/\/pharmacology.uthscsa.edu\/faculty\/Folli.asp\">Franco Folli, M.D., Ph.D.<\/a>, professor of medicine in the Diabetes Division of the <a href=\"https:\/\/som.uthscsa.edu\">School of Medicine<\/a>. The studies were carried out by researchers at Boston Children\u2019s Hospital and Harvard Medical School and San Raffaele Hospital in Milan, Italy, led by Paolo Fiorina, M.D., Ph.D.<\/p>\n<p>\u201cIn patients with Type 1 diabetes, the cell lining of the intestine was damaged,\u201d Dr. Folli said. \u201cThe stem cells that maintain this lining, called colonic stem cells, were altered. The culprit is found in a protein called insulin-like growth factor binding protein 3, which is produced in the liver and in higher amounts in Type 1 diabetes. It binds to a receptor protein on colonic stem cells, causing their death and, in turn, damaging the intestinal lining.\u201d<\/p>\n<p>The team also experimented with a biopharmaceutical that blocks circulating levels of the protein. Studies in diabetic mice show that the drug can reverse the colon damage.<\/p>\n<p>\u201cThis has the potential to result in a new treatment for this chronic complication of longstanding Type 1 diabetes,\u201d Dr. Folli said.<\/p>\n<p>The findings were published in <i>Cell Stem Cell<\/i>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers find new clues about chronic GI ailments in patients with Type 1 diabetes.<\/p>\n","protected":false},"author":23,"featured_media":5450,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[63,155],"tags":[108],"ppma_author":[282],"class_list":["post-4875","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-university-in-motion","category-fall15-winter16","tag-diabetes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chronic complication in diabetics explained - Mission Magazine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chronic complication in diabetics explained - Mission Magazine\" \/>\n<meta property=\"og:description\" content=\"Researchers find new clues about chronic GI ailments in patients with Type 1 diabetes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/\" \/>\n<meta property=\"og:site_name\" content=\"Mission Magazine\" \/>\n<meta property=\"article:published_time\" content=\"2016-01-07T14:20:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2016-05-27T20:12:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"contributor\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"contributor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/\"},\"author\":{\"name\":\"contributor\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#\\\/schema\\\/person\\\/ffb145426f57a0322ba63b1cd767873e\"},\"headline\":\"Chronic complication in diabetics explained\",\"datePublished\":\"2016-01-07T14:20:50+00:00\",\"dateModified\":\"2016-05-27T20:12:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/\"},\"wordCount\":252,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/wp-content\\\/uploads\\\/sites\\\/20\\\/2016\\\/01\\\/stomache-ache-600px.jpg\",\"keywords\":[\"diabetes\"],\"articleSection\":[\"University in Motion\",\"Fall 2015\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/\",\"url\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/\",\"name\":\"Chronic complication in diabetics explained - Mission Magazine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/wp-content\\\/uploads\\\/sites\\\/20\\\/2016\\\/01\\\/stomache-ache-600px.jpg\",\"datePublished\":\"2016-01-07T14:20:50+00:00\",\"dateModified\":\"2016-05-27T20:12:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#primaryimage\",\"url\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/wp-content\\\/uploads\\\/sites\\\/20\\\/2016\\\/01\\\/stomache-ache-600px.jpg\",\"contentUrl\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/wp-content\\\/uploads\\\/sites\\\/20\\\/2016\\\/01\\\/stomache-ache-600px.jpg\",\"width\":600,\"height\":400},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/chronic-complication-in-diabetics-explained\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Chronic complication in diabetics explained\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#website\",\"url\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/\",\"name\":\"Mission Magazine\",\"description\":\"The University of Texas Health Science Center at San Antonio Mission magazine\",\"publisher\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#organization\",\"name\":\"Mission Magazine\",\"url\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/wp-content\\\/uploads\\\/sites\\\/20\\\/2024\\\/10\\\/UTHSA_logo_H_CMYK-350.jpg\",\"contentUrl\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/wp-content\\\/uploads\\\/sites\\\/20\\\/2024\\\/10\\\/UTHSA_logo_H_CMYK-350.jpg\",\"width\":350,\"height\":121,\"caption\":\"Mission Magazine\"},\"image\":{\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/#\\\/schema\\\/person\\\/ffb145426f57a0322ba63b1cd767873e\",\"name\":\"contributor\",\"url\":\"https:\\\/\\\/magazines.uthscsa.edu\\\/mission\\\/author\\\/communications\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Chronic complication in diabetics explained - Mission Magazine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/","og_locale":"en_US","og_type":"article","og_title":"Chronic complication in diabetics explained - Mission Magazine","og_description":"Researchers find new clues about chronic GI ailments in patients with Type 1 diabetes.","og_url":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/","og_site_name":"Mission Magazine","article_published_time":"2016-01-07T14:20:50+00:00","article_modified_time":"2016-05-27T20:12:26+00:00","og_image":[{"width":600,"height":400,"url":"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg","type":"image\/jpeg"}],"author":"contributor","twitter_card":"summary_large_image","twitter_misc":{"Written by":"contributor","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#article","isPartOf":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/"},"author":{"name":"contributor","@id":"https:\/\/magazines.uthscsa.edu\/mission\/#\/schema\/person\/ffb145426f57a0322ba63b1cd767873e"},"headline":"Chronic complication in diabetics explained","datePublished":"2016-01-07T14:20:50+00:00","dateModified":"2016-05-27T20:12:26+00:00","mainEntityOfPage":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/"},"wordCount":252,"commentCount":0,"publisher":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/#organization"},"image":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#primaryimage"},"thumbnailUrl":"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg","keywords":["diabetes"],"articleSection":["University in Motion","Fall 2015"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/","url":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/","name":"Chronic complication in diabetics explained - Mission Magazine","isPartOf":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/#website"},"primaryImageOfPage":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#primaryimage"},"image":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#primaryimage"},"thumbnailUrl":"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg","datePublished":"2016-01-07T14:20:50+00:00","dateModified":"2016-05-27T20:12:26+00:00","breadcrumb":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#primaryimage","url":"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg","contentUrl":"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2016\/01\/stomache-ache-600px.jpg","width":600,"height":400},{"@type":"BreadcrumbList","@id":"https:\/\/magazines.uthscsa.edu\/mission\/chronic-complication-in-diabetics-explained\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/magazines.uthscsa.edu\/mission\/"},{"@type":"ListItem","position":2,"name":"Chronic complication in diabetics explained"}]},{"@type":"WebSite","@id":"https:\/\/magazines.uthscsa.edu\/mission\/#website","url":"https:\/\/magazines.uthscsa.edu\/mission\/","name":"Mission Magazine","description":"The University of Texas Health Science Center at San Antonio Mission magazine","publisher":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/magazines.uthscsa.edu\/mission\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/magazines.uthscsa.edu\/mission\/#organization","name":"Mission Magazine","url":"https:\/\/magazines.uthscsa.edu\/mission\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/magazines.uthscsa.edu\/mission\/#\/schema\/logo\/image\/","url":"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2024\/10\/UTHSA_logo_H_CMYK-350.jpg","contentUrl":"https:\/\/magazines.uthscsa.edu\/mission\/wp-content\/uploads\/sites\/20\/2024\/10\/UTHSA_logo_H_CMYK-350.jpg","width":350,"height":121,"caption":"Mission Magazine"},"image":{"@id":"https:\/\/magazines.uthscsa.edu\/mission\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/magazines.uthscsa.edu\/mission\/#\/schema\/person\/ffb145426f57a0322ba63b1cd767873e","name":"contributor","url":"https:\/\/magazines.uthscsa.edu\/mission\/author\/communications\/"}]}},"authors":[{"term_id":282,"user_id":23,"is_guest":0,"slug":"communications","display_name":"contributor","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/fe5d595b1ed682963b6a3444e8d8fb1d5d728dd56bd10b167f41c3ced488a8e7?s=96&d=mm&r=g","author_category":"","first_name":"UTHSCSA","last_name":"contributor","user_url":"","job_title":"","description":""}],"_links":{"self":[{"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/posts\/4875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/comments?post=4875"}],"version-history":[{"count":0,"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/posts\/4875\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/media\/5450"}],"wp:attachment":[{"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/media?parent=4875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/categories?post=4875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/tags?post=4875"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/magazines.uthscsa.edu\/mission\/wp-json\/wp\/v2\/ppma_author?post=4875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}