{"id":10979,"date":"2018-01-23T09:54:29","date_gmt":"2018-01-23T09:54:29","guid":{"rendered":"https:\/\/magazines.uthscsa.edu\/mission-new\/?p=10979"},"modified":"2018-02-05T21:04:56","modified_gmt":"2018-02-05T21:04:56","slug":"locked-in-brain-injury","status":"publish","type":"post","link":"https:\/\/magazines.uthscsa.edu\/mission\/locked-in-brain-injury\/","title":{"rendered":"Locked in"},"content":{"rendered":"

\"\"<\/em><\/h3>\n

By <\/em>Will Sansom<\/strong><\/p>\n

Some children narrowly escape the horrors of drowning only to face a different kind of suffering: trapped inside their own bodies, awake but paralyzed, communicating by eye movements and sounds, unable to walk, speak or eat. Researchers at UT Health San Antonio identify it as \u201cpost-drowning locked-in syndrome.\u201d New imaging studies reveal that cognitive and sensory networks are preserved in the brains of these children. The injury does not, as formerly believed, impact the entire brain, but is confined to a small area. The findings support parents\u2019 conviction that their locked-in children are experiencing emotions, learning new ideas and developing personalities. The research also creates hope that someday the brain injury will be treatable.<\/em><\/h3>\n

Michael\u2019s story<\/i><\/p>\n

Sabine Summerville remembers the day as if it were yesterday. In a matter of minutes on an autumn afternoon, her son Michael\u2019s life changed in a few feet of water.<\/p>\n

Michael, the seventh of Sabine and Bill Summerville\u2019s nine children, was 21 months old when he drowned in a swimming pool and was resuscitated in October 2008. Eleven children were running around the pool, making cardboard duct-taped boats in a competition to see whose would float the best.<\/p>\n

\u201cIt was just a few moments of inattentiveness,\u201d she said. \u201cHonestly, when we got him out of the water I thought it would be fine. I did CPR [cardiopulmonary resuscitation], but it just didn\u2019t work.\u201d<\/p>\n

Michael was in an unmedicated coma for weeks. It took him six months to slowly regain awareness. Today Michael is 11 and in a wheelchair, completely limited physically.<\/p>\n

\u201cI used to believe he had some purposeful movement, but now I think it is all spastic,\u201d his mother said.<\/p>\n

Two nurses help care for Michael during the week, giving him 24\/7 management of his breathing issues and seizures. Locked-in children develop muscle contractures in areas where stretchy muscle is replaced by inelastic, fibrous muscle. Michael arches his neck backward, which tilts his head back, and because his lower jaws are contracted, he can\u2019t close his mouth.<\/p>\n

\u201cIt is a constant vigil readjusting his head and helping him close his mouth so he can breathe well,\u201d Summerville said. \u201cYou can imagine it\u2019s not comfortable to breathe.\u201d<\/p>\n

When Michael is calm, his muscles relax and he breathes better, she said. But then there are the seizures.<\/p>\n

Michael may go two or three months without one and then have a spike in activity. After a scoliosis surgery in January 2017, he had seizures multiple times a day for several weeks.<\/p>\n

The family was told he\u2019d never be able to communicate. Yet this locked-in child does so\u2014frequently.<\/p>\n

\u201cCognitively, I believe he is a typical 11-year-old boy,\u201d she said. \u201cHe understands literature and prefers watching documentaries. In fact, he would rather watch what the adults are watching. He likes being included in family life as much as possible.\u201d<\/p>\n

Michael makes quiet vocalizations, like a moan or a hum, and vowel sounds when feeling content. Every now and then\u2014once or twice a week\u2014he even smiles.<\/p>\n

\u201cHis dad is the one who really gets him to smile,\u201d Summerville said.<\/p>\n

Michael enjoys listening to stories, particularly descriptions of the rugged Western environment in Louis L\u2019Amour audiobooks. Documentaries about nature and heavy-duty machines used in construction are among his favorite subjects.<\/p>\n

\u201cHe likes action and paints a picture in his mind of what he is hearing,\u201d she said.<\/p>\n

\"Liz
Conrad Tullis was just 17 months old when he was diagnosed with anoxic brain injury caused by lack of oxygen to the brain after drowning in a swimming pool. His mother, Liz Tullis, serves as co-author with Peter T. Fox, M.D., director of the Research Imaging Institute, on studies that show damage is confined to a single motor pathway in the brain.
Photo: \u00a9 Julysa Sosa \/ San Antonio Express-News via ZUMA Wire<\/figcaption><\/figure>\n

Conrad\u2019s story<\/i><\/p>\n

Liz Tullis\u2019 phone rang in January 2004, and it was the call no parent ever wants to receive. Her active 17-month-old toddler, Conrad, was visiting his grandparents in Temple, Texas, when he wandered into their swimming pool. He drowned and couldn\u2019t be resuscitated until arriving at a nearby hospital.<\/p>\n

She was out of the country at the time and only able to hear updates by phone.<\/p>\n

\u201cWe never knew how long he was in the water,\u201d Tullis said. \u201cI was told he coded more than once at the hospital. They did everything they could to save him.\u201d<\/p>\n

Conrad was diagnosed with anoxic brain injury caused by lack of oxygen to the brain. At the time, not a lot was known about the post-drowning syndrome. What doctors did know is that Conrad would never walk or talk again.<\/p>\n

\u201cThey told me Conrad was going to live, but they also said he would never get better, never express emotion,\u201d she said. \u201cThey encouraged me to institutionalize him. Inside me there was a mixture of spiritual\u2014hope\u2014and intellectual\u2014\u2018Do we really know he can\u2019t recover?\u2019\u201d<\/p>\n

She became acquainted with other parents and a common observation emerged, however. The children, seemingly locked in and unable to communicate, were surpassing doctors\u2019 expectations.<\/p>\n

\u201cVerbally is just one way people communicate,\u201d Tullis said. \u201cWe all have a repertoire of facial expressions, and Conrad is no different. Just looking at him, you can see what kind of mood he\u2019s in. Definitely we like the smiles. If a conversation is going on, he reacts appropriately. If I say I\u2019m going somewhere, he looks at me like, \u2018Where are you going?\u2019 It\u2019s the same type of expressions that you would be able to understand from somebody who can talk and just isn\u2019t. If he\u2019s in pain, he makes a pained face. If he\u2019s happy, he makes a happy face.<\/p>\n

\u201cWe make him vocalize,\u201d she said. \u201cIf we\u2019re going somewhere, we say, \u2018Do you want to go?\u2019 and he has to make a small noise saying, \u2018Yes, I want to go.\u2019\u201d<\/p>\n

Now 15, Conrad attends Alamo Heights High School. School staff members send pictures and notes to tell his mother what\u2019s going on so she can ask Conrad about it.<\/p>\n

\u201cHe expresses whether something made him happy or sad or excited,\u201d she said. \u201cSchool staff also tell me Conrad knows when it\u2019s going to be the next period and somebody is going to take him. They are definite about that.<\/p>\n

\u201cIf I have him in a room and I have to go into another room, and if he feels I haven\u2019t come back soon enough, he will let out this huge yell, like, \u2018Get back in here.\u2019 And whenever I have an audiobook of Moby-Dick<\/i> playing, he sits there and listens every time and will not move. He\u2019s been through the whole book. A friend of ours was talking about Moby-Dick<\/i>, and Conrad turned his head straight over to the person and recognized the part of the book being discussed.\u201d<\/p>\n

Out of her experiences with Conrad and a desire to help other families, Tullis established the Conrad Smiles Fund. The fund has provided support to UT Health San Antonio research, such as networking with parents to seek their children\u2019s participation in clinical studies.<\/p>\n

\u201cWe were told Conrad would not be able to smile or show emotion,\u201d she said. \u201cBut what the doctors learned in medical school was different from what we were experiencing. We\u2019re with our kids all the time. We know. The facial cues and the sounds mean something.\u201d<\/p>\n

The research<\/i><\/p>\n

Peter T. Fox, M.D., director of the Research Imaging Institute and professor in the Joe R. & Teresa Lozano Long School of Medicine, set out to find the science to prove their belief.<\/p>\n

Drowning is the most frequent cause of unintentional injury and death in children less than 4 years of age, with more than 3,500 cases annually in the United States. Two-thirds of the time, the children survive thanks to successful CPR.<\/p>\n

For the children who survive, but are \u201clocked in,\u201d the prognosis is grim.<\/p>\n

\u201cWhen someone inhales water, very quickly the heart stops beating,\u201d Dr. Fox said. \u201cThe brain is the organ that\u2019s greediest for oxygen. The lack of oxygen causes anoxic brain injury. By the time these resuscitated children arrive at emergency departments, they are either comatose or convulsing.\u201d<\/p>\n

Dr. Fox, who met the Tullis family in 2010, is trained in radiology, neurology and psychiatry, and uniquely suited to profile these children. With funding from the Kronkosky Charitable Foundation, he designed a series of studies to better understand post-drowning locked-in syndrome. The team, consisting of two doctoral students and two research staff, published its research over multiple years, including three papers in 2017. The work is changing the way these children are viewed by the medical establishment.<\/p>\n

\u201cThis is a new syndrome,\u201d Dr. Fox said. \u201cIt\u2019s not taught in medical school. This is all new neuroscience.\u201d<\/p>\n

The researchers studied brain images of 10 children, including Michael and Conrad, and compared them to corresponding images taken in 10 healthy children. What they found confirmed their predictions and supported the experiences that parents were having with their locked-in children.<\/p>\n

The studies showed the injury is much more restricted in scope than was previously believed. Rather than impacting the entire brain, the injury is confined to a single motor pathway. Paralysis results from injury to this pathway.<\/p>\n

\"\"
Scans with colored overlays of 11 brain networks in children with anoxic brain injury and healthy children show significant differences in two motor networks, the basal ganglia and cerebellum, as well as the left frontoparietal, highlighted in green. Blue shows where tissue is missing or damaged in the children with anoxic brain injury. Pink highlights tissue that is preserved in children with anoxic brain injury that matches healthy children. Areas in red are regions in which neurons adapted to change, or were repurposed, in injured children. These areas could aid in functional recovery, the researchers believe.<\/figcaption><\/figure>\n

\u201cRather than finding damage everywhere, as everyone else expected, the injury turned out to be a small stroke,\u201d Dr. Fox said. \u201cBecause the injury is adjacent to a blood vessel that can be accessed via catheter, it should be feasible to deliver medication to the site. This could, potentially, save children from being locked in.\u201d<\/p>\n

Administering clot-busting drugs used to treat an adult stroke will not work, he said, because the injury is far different, not caused by arterial plaque buildup. An agent that protects the brain would be ideal. Many ideas are being tossed about, including research at UT Health San Antonio that proposes to stimulate activity of caretaker cells called astrocytes in response to brain injury.<\/p>\n

The studies also demonstrate that visual, auditory, tactile and cognitive networks are preserved in the children. This explains why the children track with their eyes, hear commands, respond to touch, and enjoy stories they hear or watch.<\/p>\n

\u201cOur observations suggest that the severe motor deficits observed in this population can mask relatively intact perceptual and cognitive capabilities,\u201d Dr. Fox said.<\/p>\n

The brain system that\u2019s most associated with awareness is called the default-mode network. The team found a strong correlation between social behaviors and preservation of this network, he said.<\/p>\n

\u201cEven in the most severely affected of the children, we have evidence that at least the machinery for awareness of themselves and others remains functioning,\u201d he said. \u201cWe can see that the machinery is still intact.\u201d<\/p>\n

That\u2019s something that Tullis, who also serves as co-author on some of the studies, has suspected for years.<\/p>\n

\u201cThese kids grow and are cognitively aware,\u201d she said.<\/p>\n

The new findings give hope and validation to these families, Dr. Fox said.<\/p>\n

\u201cWhat\u2019s so important about this research is, now we have the science behind us,\u201d Tullis said. \u201cIf this happened to us, and we are living it, we can help others around us. We want every child, like Conrad and like Michael, to reach his maximum potential\u2014no limits.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

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