{"id":2541,"date":"2024-06-20T03:30:56","date_gmt":"2024-06-20T03:30:56","guid":{"rendered":"https:\/\/magazines.uthscsa.edu\/cancer-center\/?p=2541"},"modified":"2024-12-10T16:54:12","modified_gmt":"2024-12-10T16:54:12","slug":"mays-cancer-center-conducts-groundbreaking-glioblastoma-research","status":"publish","type":"post","link":"https:\/\/magazines.uthscsa.edu\/cancer-center\/2024\/06\/20\/mays-cancer-center-conducts-groundbreaking-glioblastoma-research\/","title":{"rendered":"Mays Cancer Center conducts groundbreaking glioblastoma research"},"content":{"rendered":"<p>Mays Cancer Center at The University of Texas Health Science Center at San Antonio recently conducted a clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma multiforme (GBM). The Mays Cancer Center, one of four National Cancer Institute-designated Cancer Centers in Texas, is the only cancer center in America to conduct this trial.<\/p>\n<p>Andrew Brenner, MD, PhD, professor of medicine at the health science center and a medical oncologist specializing in both breast cancer and malignancies of the brain and spinal cord, initiated the clinical trial.<\/p>\n<p>\u201cGlioblastoma is the most common and, unfortunately, the most aggressive primary brain tumor,\u201d Brenner said. \u201cThe average survival for a newly diagnosed GBM is 20 months, and that\u2019s only a four-month improvement in survival from 2005 when we began following surgery with chemotherapy and radiation.\u201d<\/p>\n<p>Glioblastoma has claimed the lives of many well-known figures. U.S. Sen. Edward M. Kennedy died of GBM in 2009. Beau Biden, son of U.S. President Joe Biden, succumbed to the disease in 2015. And U.S. Senator John McCain lost his battle with GBM in 2018.<\/p>\n<p>\u201cThat is the landscape in which we work,\u201d said William Kelly, MD, assistant professor of medicine at the health science center and a neuro-oncologist at Mays Cancer Center. \u201cGBM comes back after treatment in almost all patients, and, when it does, survival is extremely poor. There is a desperate need for more therapies to treat these patients.\u201d<\/p>\n<p>For the study, the Mays Cancer Center enrolled and treated 25 patients with GBM. Treatment consisted of a standard-of-care chemotherapy called bevacizumab (brand name Avastin) combined with a small-molecule fatty acid synthase inhibitor called TVB-2640 (Denifanstat), since glioblastoma tumors rely on their ability to make fatty acids for growth.<\/p>\n<p>Side effects such as rashes, dry eye and fatigue were mild, and researchers noted an improvement in sixmonth, progression-free survival.<\/p>\n<p>No current therapy improves survival in recurrent GBM. The overall survival of participants in the Mays Cancer Center study was not statistically significant compared to historical controls \u2014 patients with highgrade GBMs who weren\u2019t in the study and were treated with bevacizumab only. However, the fact that the drug combination was able to stop cancer progression for six months in a greater number of patients with highgrade GBM was noteworthy, according to Kelly.<\/p>\n<figure id=\"attachment_2542\" aria-describedby=\"caption-attachment-2542\" style=\"width: 200px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-2542\" src=\"https:\/\/magazines.uthscsa.edu\/cancer-center\/wp-content\/uploads\/sites\/12\/2024\/06\/kelly.jpg\" alt=\"Dr. William Kelly's headshot\" width=\"200\" height=\"250\" \/><figcaption id=\"caption-attachment-2542\" class=\"wp-caption-text\">William J. Kelly, MD, assistant professor of medicine and a<br \/>neuro-oncologist at Mays Cancer Center.<\/figcaption><\/figure>\n<p>\u201cThis gives us hope, although we are always simultaneously realistic about the disappointing history of treating these diseases,\u201d Kelly said.<\/p>\n<p>Results of the study were published in Clinical Cancer Research, a journal of the American Association for Cancer Research.<\/p>\n<h3 style=\"text-align: right\">\u201cThe fact that the drug combination of bevacizumab (brand name Avastin) combined with a smallmolecule fatty acid synthase inhibitor called TVB-2640 (Denifanstat) was able to arrest cancer progression for six months in a greater number of patients with highgrade GBM was noteworthy.&#8221;<\/h3>\n<h5 style=\"text-align: right\"><strong>\u2013 William J. Kelly<\/strong>, MD, assistant professor of medicine and a neuro-oncologist at Mays Cancer Center<\/h5>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mays Cancer Center at The University of Texas Health Science Center at San Antonio recently conducted a clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma multiforme (GBM). The Mays Cancer Center, one of four National Cancer Institute-designated Cancer Centers in Texas, is the only cancer center in America to conduct this trial. <\/p>\n","protected":false},"author":653,"featured_media":2543,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[67],"magazine":[22],"issue-year":[65],"featured-story":[36],"class_list":["post-2541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-the-power-of-hope","magazine-cancer-center","issue-year-65","featured-story-homepage"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mays Cancer Center conducts groundbreaking glioblastoma research - Mays Cancer Center Annual Report<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/magazines.uthscsa.edu\/cancer-center\/2024\/06\/20\/mays-cancer-center-conducts-groundbreaking-glioblastoma-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mays Cancer Center conducts groundbreaking glioblastoma research - Mays Cancer Center Annual Report\" \/>\n<meta property=\"og:description\" content=\"Mays Cancer Center at The University of Texas Health Science Center at San Antonio recently conducted a clinical trial combining two drugs in patients with recurrent, high-grade glioblastoma multiforme (GBM). 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