{"id":2484,"date":"2024-06-20T04:00:41","date_gmt":"2024-06-20T04:00:41","guid":{"rendered":"https:\/\/magazines.uthscsa.edu\/cancer-center\/?p=2484"},"modified":"2024-07-03T20:41:37","modified_gmt":"2024-07-03T20:41:37","slug":"repurposed-drug-brings-new-hope-for-breast-cancer-patients","status":"publish","type":"post","link":"https:\/\/magazines.uthscsa.edu\/cancer-center\/2024\/06\/20\/repurposed-drug-brings-new-hope-for-breast-cancer-patients\/","title":{"rendered":"Repurposed drug brings new hope for breast cancer patients"},"content":{"rendered":"<h2>Mays Cancer Center scientists are testing whether medications for conditions unrelated to cancer might contribute to successful outcomes for breast cancer patients.<\/h2>\n<h3 style=\"text-align: right\"><em>\u201cThe patient is always the focus of the work being done in both the lab and the clinic, as it should be. Curing cancer in a lab is great, but it\u2019s not the ultimate goal. Curing cancer in patients is.\u201d<\/em><\/h3>\n<h5 style=\"text-align: right\"><strong>\u2013 Virginia G. Kaklamani<\/strong>, MD, professor of medicine and leader of the breast oncology program at Mays Cancer Center<\/h5>\n<figure id=\"attachment_2490\" aria-describedby=\"caption-attachment-2490\" style=\"width: 400px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2490 size-full\" src=\"https:\/\/magazines.uthscsa.edu\/cancer-center\/wp-content\/uploads\/sites\/12\/2024\/06\/kaklamani.jpg\" alt=\"Dr. Virginia Kaklamani examines a patient's throat in an exam room.\" width=\"400\" height=\"200\" \/><figcaption id=\"caption-attachment-2490\" class=\"wp-caption-text\">Virginia G. Kaklamani, MD, professor of medicine and leader of the breast oncology program at Mays Cancer Center<\/figcaption><\/figure>\n<p>Could a drug prescribed for transplant recipients also help some women beat breast cancer? Impressive new findings point to this possibility, according to research conducted at The University of Texas Health Science Center at San Antonio.<\/p>\n<p>Kimi Kong, PhD, and Robert Hromas, MD, FACP, who made the observations, are collaborating with Virginia Kaklamani, MD, DSc, to offer a clinical trial of the drug cyclosporin at the Mays Cancer Center.<\/p>\n<p>Kong, associate professor of medicine, and Hromas, acting president of UT Health San Antonio, found that cyclosporin kills a specific type of cancer cell. They immediately contacted Kaklamani, leader of the Breast Oncology Program at the Mays Cancer Center.<\/p>\n<p>In the cyclosporin study, the cancer center\u2019s patient care and scientific discovery missions are powerfully fused. The hope is to discover another treatment option to help the hundreds of thousands of individuals \u2014 predominantly women \u2014 who are diagnosed with breast cancer each year in the U.S., including more than 20,000 new cases annually in Texas.<\/p>\n<p>Cyclosporin has a history of safety in humans dating back four decades. The U.S. Food and Drug Administration approved the drug in 1983 to prevent the rejection of transplanted organs. Kaklamani\u2019s challenge is to define the best use of this drug in a new population of patients.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-2491 size-full\" src=\"https:\/\/magazines.uthscsa.edu\/cancer-center\/wp-content\/uploads\/sites\/12\/2024\/06\/breast_cancer.jpg\" alt=\"Centers for Disease Control and Prevention stats on breast cancer prevalence in women and men.\" width=\"320\" height=\"286\" \/>As findings are made by Kong, Hromas and the research team, they are communicated to Kaklamani and the clinical team at the Mays Cancer Center.<\/p>\n<p>Over the next several years, Kaklamani will study cyclosporin in women newly diagnosed with one type of inherited breast cancer who have not yet received any treatment.<\/p>\n<p>\u201cWe know the dose for transplant patients, but we are not using the drug for transplantation,\u201d she said. \u201cShould we be using the same dose for our cancer patients? This study will answer many questions.\u201d<\/p>\n<p>The clinical trial is supported by funding from the National Institutes of Health and the Mays Cancer Center.<\/p>\n<p>\u201cThe patient is always the focus of the work being done in both the lab and the clinic, as it should be,\u201d Kaklamani said. \u201cCuring cancer in a lab is great, but it\u2019s not the ultimate goal. Curing cancer in patients is.\u201d<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Could a drug prescribed for transplant recipients also help some women beat breast cancer? Impressive new findings point to this possibility, according to research conducted at The University of Texas Health Science Center at San Antonio that is now being used in a clinical trial supported by funding from the National Institutes of Health and the Mays Cancer Center. <\/p>\n","protected":false},"author":653,"featured_media":2641,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[52,68],"magazine":[22],"issue-year":[65],"featured-story":[36],"class_list":["post-2484","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-therapies","category-the-power-of-solutions","magazine-cancer-center","issue-year-65","featured-story-homepage"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Repurposed drug brings new hope for breast cancer patients - Mays Cancer Center Annual Report<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/magazines.uthscsa.edu\/cancer-center\/2024\/06\/20\/repurposed-drug-brings-new-hope-for-breast-cancer-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Repurposed drug brings new hope for breast cancer patients - Mays Cancer Center Annual Report\" \/>\n<meta property=\"og:description\" content=\"Could a drug prescribed for transplant recipients also help some women beat breast cancer? 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