{"id":2481,"date":"2024-06-20T05:00:42","date_gmt":"2024-06-20T05:00:42","guid":{"rendered":"https:\/\/magazines.uthscsa.edu\/cancer-center\/?p=2481"},"modified":"2024-07-03T20:40:39","modified_gmt":"2024-07-03T20:40:39","slug":"molecule-shows-potential-to-combat-tumor-treatment-resistance","status":"publish","type":"post","link":"https:\/\/magazines.uthscsa.edu\/cancer-center\/2024\/06\/20\/molecule-shows-potential-to-combat-tumor-treatment-resistance\/","title":{"rendered":"Molecule shows potential to combat tumor treatment resistance"},"content":{"rendered":"

Researchers are investigating multiple approaches to combat the deadliest form of brain cancer, giving patients and their families greater hope.<\/h2>\n

The highly devastating brain tumor glioblastoma multiforme (GBM) has long posed treatment challenges, as effective therapies have remained elusive. Despite responding initially to treatment, GBM patients often experience therapy resistance, leading to low long-term survival rates.<\/p>\n

Researchers at Mays Cancer Center and from the Department of Obstetrics and Gynecology at The University of Texas Health Science Center at San Antonio have made significant progress in studying a promising new molecule that inhibits the ability of GBM tumors to repair themselves.<\/p>\n

Published in the prestigious journal of Neuro-Oncology in January 2023, the study demonstrated that mice receiving this novel therapy in combination with chemotherapy showed extended survival compared to those receiving a single drug alone.<\/p>\n

The molecule, known as NCD38, targets a specific subset of GBM cells called glioma stem cells. By disrupting their highly efficient DNA repair activity, NCD38 offers new possibilities for treatment.<\/p>\n

\u201cGlioma stem cells are notoriously difficult to treat,\u201d said Gangadhara Sareddy, PhD, corresponding study author and a Mays Cancer Center investigator and associate professor of obstetrics and gynecology at the health science center.<\/p>\n

Chemotherapy and radiation primarily damage the DNA of glioblastoma tumor cells, slowing tumor growth. However, glioma stem cells possess an elevated ability to repair this DNA damage, contributing to treatment resistance. NCD38 inhibits an enzyme called Lysine-Specific Histone Demethylase 1A (KDM1A), which plays a significant role in DNA repair within glioblastoma.<\/p>\n

\u201cWhile mice in the non-treatment group succumbed to GBM within two to three weeks of implantation, those in the combination therapy group \u2014 NCD38 with temozolomide \u2014 survived four to five weeks.\u201d<\/p><\/blockquote>\n

\u2013 Gangadhara Sareddy<\/strong>, PhD, associate professor, Department of Obstetrics and Gynecology<\/h5>\n
\"Dr.
Gangadhara Sareddy, PhD, associate professor, Department of Obstetrics and Gynecology<\/figcaption><\/figure>\n

\u201cThis enzyme is highly expressed in glioblastoma, and patients with elevated KDM1A expression tend to exhibit poorer overall survival,\u201d Sareddy explained.<\/p>\n

The study involved implanting GBM tumors into mice, followed by randomization into treatment groups. The mice in the treatment groups were assigned to receive either NCD38, the chemotherapy drug temozolomide or a combination of both. A control group received a nonactive placebo.<\/p>\n

The mice receiving the combination of NCD38 and temozolomide demonstrated the longest survival rates. By inhibiting KDM1A activity and interfering with the cancer\u2019s DNA repair, NCD38 enhanced the cancer-killing effects of temozolomide.<\/p>\n

\u201cWhile mice in the non-treatment group succumbed to GBM within two to three weeks of implantation, those in the combination therapy group \u2014 NCD38 with temozolomide \u2014 survived four to five weeks,\u201d Sareddy said.<\/p>\n

While the study is yet to be conducted in humans, the potential benefits observed in mice could translate into significant survival improvements of two to three years for patients.<\/p>\n

\"Salvador
Salvador Alejo, medical student in the South Texas Medical Scientist Training Program at The University of Texas Health Science Center at San Antonio.<\/figcaption><\/figure>\n

\u201cIdentifying mechanisms that regulate DNA repair in glioma stem cells may unveil new paradigms to curb GBM growth and recurrence, ultimately improving patient outcomes,\u201d noted lead author Salvador Alejo, a medical student in the South Texas Medical Scientist Training Program at the health science center. His research focused on this topic.<\/p>\n

Further studies are needed to evaluate the safety and efficacy of this treatment strategy. Nonetheless, promising results from this study provide hope for developing new strategies to combat GBM treatment resistance and pave the way for enhanced patient care.<\/p>\n

<\/h5>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers at Mays Cancer Center and from the Department of Obstetrics and Gynecology at The University of Texas Health Science Center at San Antonio have made significant progress in studying a promising new molecule that inhibits the ability of glioblastoma multiforme (GBM) tumors to repair themselves. <\/p>\n","protected":false},"author":653,"featured_media":2639,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[67],"magazine":[22],"issue-year":[65],"featured-story":[36],"class_list":["post-2481","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-the-power-of-hope","magazine-cancer-center","issue-year-65","featured-story-homepage"],"yoast_head":"\nMolecule shows potential to combat tumor treatment resistance - Mays Cancer Center Annual Report<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/magazines.uthscsa.edu\/cancer-center\/2024\/06\/20\/molecule-shows-potential-to-combat-tumor-treatment-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecule shows potential to combat tumor treatment resistance - 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