{"id":2247,"date":"2023-05-13T03:45:05","date_gmt":"2023-05-13T03:45:05","guid":{"rendered":"https:\/\/magazines.uthscsa.edu\/cancer-center\/?p=2247"},"modified":"2023-05-19T07:59:07","modified_gmt":"2023-05-19T07:59:07","slug":"promising-compound-kills-range-of-hard-to-treat-cancers","status":"publish","type":"post","link":"https:\/\/magazines.uthscsa.edu\/cancer-center\/2023\/05\/13\/promising-compound-kills-range-of-hard-to-treat-cancers\/","title":{"rendered":"Promising compound kills range of hard-to-treat cancers"},"content":{"rendered":"

\u201cThe huge advances in cancer science are leading to the creation of new medications. Finding novel methods for cancer prevention, diagnosis and therapy requires ongoing cancer research.\u201d<\/em><\/h3>\n
\u2014 Ratna Vadlamudi, PhD<\/strong>,\u00a0Professor and Vice Chair for Research, Department of Obstetrics and Gynecology<\/h5>\n

<\/h3>\n

In 2017, Ratna Vadlamudi, PhD, a professor of obstetrics and gynecology at the Mays Cancer Center, identified a compound called ERX-11 that targets the estrogen receptor (ER), a protein that drives the vast majority of breast cancers. From a screen of chemical analogs of ERX-11, he and his colleagues identified that a compound called ERX-41 not only kills ER-positive cancers in petri dishes, but also readily kills triple-negative breast cancers (TNBCs) \u2014 including more than 20 distinct TNBC cell lines.<\/p>\n

The researchers expanded these studies to show ERX-41 is efficacious against a large number of human tumors grown from cell lines in mouse models. In addition, ERX-41 was found to be potent against patient-derived xenografts as well, causing shrinkage of these human tumors without affecting normal breast cells or causing any discernible toxicity.<\/p>\n

\u201cThe safety profile and high therapeutic index of this compound is particularly notable and bodes well for clinical translation,\u201d Vadlamudi said.<\/p>\n

Other experiments showed that in addition to ER-positive breast cancers and TNBC, ERX-41 is also effective against other cancer types with elevated endoplasmic reticulum stress, including pancreatic, glioblastoma and ovarian cancers, which all currently have few effective treatments.<\/p>\n

\u201cThe range of cell lines and xenografts in which the compound is known to work indicates that it is targeting a fundamental vulnerability in cancer cells,\u201d Vadlamudi said.<\/p>\n

The findings, first published in Nature Cancer<\/em>, could eventually lead to new drugs to fight these cancers. Plans are underway to move these drugs into clinical trials in 2023.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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